Anger Self-Management Training for Chronic Moderate to Severe Traumatic Brain Injury: Results of a Randomized Controlled Trial

The effect of curcumin in the recovery of severe traumatic brain injury: a double-blind randomized controlled trial

Background: Traumatic brain injury is one of the most important causes of death in trauma patients among the different types of trauma worldwide. In this study, the effect of curcumin on the outcome of severe traumatic brain injury,. Methods: This was a double-blind and paralleled randomized controlled study that was conducted on 128 patients aged 18 to 70 with severe brain trauma. Patients we...

Self-management support for moderate-to-severe chronic obstructive pulmonary disease: a pilot randomised controlled trial.

BACKGROUND Better self management could improve quality of life (QoL) and reduce hospital admissions in chronic obstructive pulmonary disease (COPD), but the best way to promote it remains unclear. AIM To explore the feasibility, effectiveness and cost effectiveness of a novel, layperson-led, theoretically driven COPD self-management support programme. DESIGN AND SETTING Pilot randomised c...

Placebo-controlled trial of amantadine for severe traumatic brain injury.

BACKGROUND Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury. Preliminary studies have suggested that amantadine may promote functional recovery. METHODS We enrolled 184 patients who were in a vegetative or minimally conscious state 4 to 16 weeks after traumatic brain injury and who w...

Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury

BACKGROUND The Erythropoietin in Traumatic Brain Injury (EPO-TBI) trial aims to determine whether the administration of erythropoietin to patients with moderate or severe traumatic brain injury improves patient-centred outcomes. METHODS EPO-TBI is a multicentre, blinded, randomised, parallel groups, placebo-controlled, phase III superiority trial of erythropoietin in ICU patients with traumat...

Moderate and Severe Traumatic Brain Injury